2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2418):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-180612
    (25R)-3α,7α,12α-Trihydroxy-5β-cholestan-26-oyl-CoA
    (25R)-3α,7α,12α-Trihydroxy-5β-cholestan-26-oyl-CoA is a nucleoside metabolite.
    (25R)-3α,7α,12α-Trihydroxy-5β-cholestan-26-oyl-CoA
  • HY-154721
    5’-O-DMTr-5-iodo-2’-dU-3’-CED phosphoramidite
    5’-O-DMTr-5-iodo-2’-dU-3’-CED phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5’-O-DMTr-5-iodo-2’-dU-3’-CED phosphoramidite
  • HY-154560
    2’,3’,5’-Tri-O-acetyl-N3-methyluridine
    2’,3’,5’-Tri-O-acetyl-N3-methyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
    2’,3’,5’-Tri-O-acetyl-N3-methyluridine
  • HY-154440
    2-Amino-6-chloro-9-(3’-O-methyl-beta-D-ribofuranosyl)-9H-purine
    2-Amino-6-chloro-9-(3’-O-methyl-beta-D-ribofuranosyl)-9H-purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-Amino-6-chloro-9-(3’-O-methyl-beta-D-ribofuranosyl)-9H-purine
  • HY-152987
    7-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-amine
    7-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects.
    7-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • HY-156826
    DiBoc-Vidarabine-Ribose(diBoc)-2-cyanoethyl-diisopropylphosphoramidite
    DiBoc-Vidarabine-Ribose(diBoc)-2-cyanoethyl-diisopropylphosphoramidite (compound 2) is used for protein modification.
    DiBoc-Vidarabine-Ribose(diBoc)-2-cyanoethyl-diisopropylphosphoramidite
  • HY-154593
    N4-Benzoyl-5’-O-DMTr-2’-O-(N3-trifluoroacetyl) aminopropyl cytidine
    N4-Benzoyl-5’-O-DMTr-2’-O-(N3-trifluoroacetyl) aminopropyl cytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N4-Benzoyl-5’-O-DMTr-2’-O-(N3-trifluoroacetyl) aminopropyl cytidine
  • HY-180777
    N-Phospho-D-lombricine
    N-Phospho-D-lombricine is a nucleoside metabolite.
    N-Phospho-D-lombricine
  • HY-152553
    4’-C-Methyl-N6-methyladenosine
    4’-C-Methyl-N6-methyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    4’-C-Methyl-N6-methyladenosine
  • HY-154674
    N1-Allylpseudouridine
    N1-Allylpseudouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N1-Allylpseudouridine
  • HY-154383
    5’-Azido-5’-deoxy-2’-O-(2-methoxyethyl)uridine
    5’-Azido-5’-deoxy-2’-O-(2-methoxyethyl)uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 5’-Azido-5’-deoxy-2’-O-(2-methoxyethyl)uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    5’-Azido-5’-deoxy-2’-O-(2-methoxyethyl)uridine
  • HY-154626
    2’-O-Hexadecanyl guanosine
    2’-O-Hexadecanyl guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-O-Hexadecanyl guanosine
  • HY-134245
    7-Deazaadenosine 5'-phosphate
    7-Deazaadenosine 5'-phosphate (Tubercidin 5'-phosphate; 7-Deaza-AMP) is a potential substrate or competitive inhibitor of enzymes that interact with 5′-adenylic acid monophosphate. As a nucleotide derivative, 7-Deazaadenosine 5'-phosphate can regulate cellular functions by affecting intracellular signaling pathways, especially in signaling involving AMP.
    7-Deazaadenosine 5'-phosphate
  • HY-154394
    2-Chloro-N6-methyl-2’-deoxyadenosine
    2-Chloro-N6-methyl-2’-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-Chloro-N6-methyl-2’-deoxyadenosine
  • HY-W395015
    5’-O-(4,4-Dimethoxytrityl)-2’-O-methyl inosine
    5’-O-(4,4-Dimethoxytrityl)-2’-O-methyl inosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5’-O-(4,4-Dimethoxytrityl)-2’-O-methyl inosine
  • HY-154420
    2’,3’-Bis-(O-t-butyldimethylsilyl)uridine
    2’,3’-Bis-(O-t-butyldimethylsilyl)uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’,3’-Bis-(O-t-butyldimethylsilyl)uridine
  • HY-154720
    3-O-Benzoyl-1,2: 5,6-bis(di-O-isopropylidene)-alpha-D-galactofuranose
    3-O-Benzoyl-1,2: 5,6-bis(di-O-isopropylidene)-alpha-D-galactofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3-O-Benzoyl-1,2: 5,6-bis(di-O-isopropylidene)-alpha-D-galactofuranose
  • HY-137626C
    Rp-ATPαS tetrasodium
    Rp-ATPαS is a monomeric raw material that can be used for nucleic acid synthesis.
    Rp-ATPαS tetrasodium
  • HY-154025
    8-Azido-2′-deoxyadenosine
    8-Azido-2′-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    8-Azido-2′-deoxyadenosine
  • HY-152661
    2-Hydroxy-2’-deoxy-2’-fluoro-beta-D-arabino adenosine
    2-Hydroxy-2’-de oxy-2’-fluoro-beta-D-arabino adenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-Hydroxy-2’-deoxy-2’-fluoro-beta-D-arabino adenosine